Cucurbitacin B Induces Hypoglycemic Effect in Diabetic Mice by Regulation of AMP-Activated Protein Kinase Alpha and Glucagon-Like Peptide-1 via Bitter Taste Receptor Signaling

Cucurbitacin B Induces Hypoglycemic Effect in Diabetic Mice by Regulation of AMP-Activated Protein Kinase Alpha and Glucagon-Like Peptide-1 via Bitter Taste Receptor Signaling

Taste receptors exist in several organs from tongue to colon and have diverse functions dependent on specific cell type. In enteroendocrine L-cells, stimulation of taste receptor signaling induces incretin hormones. Among incretin hormones, glucagon-like peptide-1 (GLP-1) induces insulinotropic acti...

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Bibliographic Details
Main Authors: Kang-Hoon Kim, In-Seung Lee, Ji Young Park, Yumi Kim, Eun-Jin An, Hyeung-Jin Jang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Pharmacology
Subjects:
cucurbitacin B
taste receptor
GLP-1
AMPK
diabetes
alpha-gustducin
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01071/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01071/full

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