Transgenic inhibition of astroglial NF-κB restrains the neuroinflammatory and neurodegenerative outcomes of experimental mouse glaucoma

Transgenic inhibition of astroglial NF-κB restrains the neuroinflammatory and neurodegenerative outcomes of experimental mouse glaucoma

Abstract Background Glia-driven neuroinflammation promotes neuron injury in glaucoma that is a chronic neurodegenerative disease of the optic nerve and a leading cause of irreversible blindness. Although therapeutic modulation of neuroinflammation is increasingly viewed as a logical strategy to avoi...

Full description

Bibliographic Details
Main Authors: Xiangjun Yang, Qun Zeng, Mine Barış, Gülgün Tezel
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Journal of Neuroinflammation
Subjects:
Astroglia
Glaucoma
IκKβ
Neurodegeneration
Neuroinflammation
NF-κB
Online Access:http://link.springer.com/article/10.1186/s12974-020-01930-1

Internet

http://link.springer.com/article/10.1186/s12974-020-01930-1

Similar Items