Mouse embryo geometry drives formation of robust signaling gradients through receptor localization

How receptor localization affects morphogen gradient formation during embryonic development is unclear. Here, the authors study the relationship between the BMP gradient, receptor localization, and compartmentalized geometry in the early mouse embryo, using experimental data and computational simula...

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Bibliographic Details
Main Authors: Zhechun Zhang, Steven Zwick, Ethan Loew, Joshua S. Grimley, Sharad Ramanathan
Format: Article
Language:English
Published: Nature Publishing Group 2019-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12533-7