Chaihu-Shugan-San exerts an antidepressive effect by downregulating miR-124 and releasing inhibition of the MAPK14 and Gria3 signaling pathways

Chaihu-Shugan-San exerts an antidepressive effect by downregulating miR-124 and releasing inhibition of the MAPK14 and Gria3 signaling pathways

Dysregulation of miR-124 has been reported to be involved in the pathophysiology of depression. Chaihu-Shugan-San, a traditional Chinese medicine, has antidepressive activity; however, the underlying mechanisms remain unclear. In this study, to generate a rodent model of depression, rats were subjec...

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Bibliographic Details
Main Authors: Qiong Liu, Ning-Ning Sun, Zheng-Zhi Wu, Da-Hua Fan, Mei-Qun Cao
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; traditional Chinese medicine; Chaihu-Shugan-San; depression; open-field test; sucrose consumption test; forced swimming test; miR-124; neural plasticity; MAPK14; Gria3; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=5;spage=837;epage=845;aulast=Liu

Internet

http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=5;spage=837;epage=845;aulast=Liu

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