Relationship between Azathioprine metabolites and therapeutic efficacy in Chinese patients with neuromyelitis optica spectrum disorders

Relationship between Azathioprine metabolites and therapeutic efficacy in Chinese patients with neuromyelitis optica spectrum disorders

Abstract Background Neuromyelitis optica spectrum disorders (NMOSD) are demyelinating autoimmune diseases in the central nervous system (CNS) that are characterized by a high relapse rate and the presence of anti-aquaporin 4 antibodies (AQP4-IgG) in the serum. Azathioprine (AZA) is a first-line immu...

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Bibliographic Details
Main Authors: Xindi Li, Shenghui Mei, Xiaoqing Gong, Heng Zhou, Li Yang, Anna Zhou, Yonghong Liu, Xingang Li, Zhigang Zhao, Xinghu Zhang
Format: Article
Language:English
Published: BMC 2017-07-01
Series:BMC Neurology
Subjects:
Neuromyelitis optica spectrum disorders (NMOSD)
Azathioprine (AZA)
Thiopurine S-methyltransferase (TPMT)
6-thioguanine nucleotides (6-TGNs)
6-methylmercaptopurine nucleotides (6-MMPNs)
Online Access:http://link.springer.com/article/10.1186/s12883-017-0903-5

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http://link.springer.com/article/10.1186/s12883-017-0903-5

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