Efficient Multiplex Gene Repression by CRISPR-dCpf1 in Corynebacterium glutamicum

Efficient Multiplex Gene Repression by CRISPR-dCpf1 in Corynebacterium glutamicum

Corynebacterium glutamicum is an important workhorse for industrial production of diversiform bioproducts. Multiplex control of metabolic pathway genes is crucial for maximizing biosynthesis of desired products. However, few tools for simultaneously regulating multiple genes in C. glutamicum have be...

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Bibliographic Details
Main Authors: Mingyue Li, Jiuzhou Chen, Yu Wang, Jiao Liu, Jingwen Huang, Ning Chen, Ping Zheng, Jibin Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
Corynebacterium glutamicum
CRISPR-dCpf1
multiplex gene repression
metabolic engineering
lysine
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00357/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2020.00357/full

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