Dose Response of Endotoxin on Hepatocyte and Muscle Mitochondrial Respiration In Vitro

Introduction. Results on mitochondrial dysfunction in sepsis are controversial. We aimed to assess effects of LPS at wide dose and time ranges on hepatocytes and isolated skeletal muscle mitochondria. Methods. Human hepatocellular carcinoma cells (HepG2) were exposed to placebo or LPS (0.1, 1, and 1...

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Bibliographic Details
Main Authors: Victor Jeger, Sebastian Brandt, Francesca Porta, Stephan M. Jakob, Jukka Takala, Siamak Djafarzadeh
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2015/353074