F-actin reorganization by V-ATPase inhibition in prostate cancer

F-actin reorganization by V-ATPase inhibition in prostate cancer

The vacuolar ATPase (V-ATPase) proton pump sustains cellular pH homeostasis, and its inhibition triggers numerous stress responses. However, the cellular mechanisms involved remain largely elusive in cancer cells. We studied V-ATPase in the prostate cancer (PCa) cell line PC-3, which has characteris...

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Bibliographic Details
Main Authors: Yamhilette Licon-Munoz, Vera Michel, Colleen A. Fordyce, Karlett J. Parra
Format: Article
Language:English
Published: The Company of Biologists 2017-11-01
Series:Biology Open
Subjects:
Vacuolar H+-ATPase proton pump
Bafilomycin A
Concanamycin A
Endo-lysosomal pH
F-actin
Prostate cancer
Online Access:http://bio.biologists.org/content/6/11/1734

Internet

http://bio.biologists.org/content/6/11/1734

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