Mitochondrial Respiratory Defect Enhances Hepatoma Cell Invasiveness via STAT3/NFE2L1/STX12 Axis

Mitochondrial Respiratory Defect Enhances Hepatoma Cell Invasiveness via STAT3/NFE2L1/STX12 Axis

Mitochondrial respiratory defects have been implicated in cancer progression and metastasis, but how they control tumor cell aggressiveness remains unclear. Here, we demonstrate that a mitochondrial respiratory defect induces nuclear factor-erythroid 2 like 1 (NFE2L1) expression at the transcription...

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Bibliographic Details
Main Authors: Young-Kyoung Lee, So Mee Kwon, Eun-beom Lee, Gyeong-Hyeon Kim, Seongki Min, Sun-Mi Hong, Hee-Jung Wang, Dong Min Lee, Kyeong Sook Choi, Tae Jun Park, Gyesoon Yoon
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cancers
Subjects:
hepatocellular carcinoma
mitochondrial defect
NFE2L1
retrograde signaling
STAT3
STX12
Online Access:https://www.mdpi.com/2072-6694/12/9/2632

Internet

https://www.mdpi.com/2072-6694/12/9/2632

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