Non-invasive imaging of disrupted protein homeostasis induced by proteasome inhibitor treatment using chemical exchange saturation transfer MRI

Non-invasive imaging of disrupted protein homeostasis induced by proteasome inhibitor treatment using chemical exchange saturation transfer MRI

Abstract Proteasome inhibitors (PIs) are now standard of care for several cancers, and noninvasive biomarkers of treatment response are critically required for early patient stratification and treatment personalization. The present study evaluated whether chemical exchange (CEST) magnetic resonance...

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Bibliographic Details
Main Authors: Yanan Zhu, Rajiv Ramasawmy, Sean Peter Johnson, Valerie Taylor, Alasdair Gibb, R. Barbara Pedley, Nibedita Chattopadhyay, Mark F. Lythgoe, Xavier Golay, Daniel Bradley, Simon Walker-Samuel
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Scientific Reports
Subjects:
Chemical Exchange Saturation Transfer (CEST)
Proteasome Inhibitor Treatment
Disrupt Protein Homeostasis
Ixazomib
CEST Signal
Online Access:https://doi.org/10.1038/s41598-018-33549-x

Internet

https://doi.org/10.1038/s41598-018-33549-x

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