Multi-Study Proteomic and Bioinformatic Identification of Molecular Overlap between Amyotrophic Lateral Sclerosis (ALS) and Spinal Muscular Atrophy (SMA)

Multi-Study Proteomic and Bioinformatic Identification of Molecular Overlap between Amyotrophic Lateral Sclerosis (ALS) and Spinal Muscular Atrophy (SMA)

Unravelling the complex molecular pathways responsible for motor neuron degeneration in amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) remains a persistent challenge. Interest is growing in the potential molecular similarities between these two diseases, with the hope of bette...

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Bibliographic Details
Main Authors: Darija Šoltić, Melissa Bowerman, Joanne Stock, Hannah K. Shorrock, Thomas H. Gillingwater, Heidi R. Fuller
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Brain Sciences
Subjects:
spinal muscular atrophy (SMA)
amyotrophic lateral sclerosis (ALS)
proteomics
bioinformatics
endoplasmic reticulum-Golgi trafficking
ER-Golgi trafficking
calreticulin (CALR)
endoplasmic reticulum
calcium
Online Access:https://www.mdpi.com/2076-3425/8/12/212

Internet

https://www.mdpi.com/2076-3425/8/12/212

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