Survival motor neuron deficiency enhances progression in an amyotrophic lateral sclerosis mouse model

Survival motor neuron deficiency enhances progression in an amyotrophic lateral sclerosis mouse model

Mutations in the ubiquitously expressed survival motor neuron 1 (SMN1) and superoxide dismutase 1 (SOD1) genes are selectively lethal to motor neurons in spinal muscular atrophy (SMA) and familial amyotrophic lateral sclerosis (ALS), respectively. Genetic association studies provide compelling evide...

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Bibliographic Details
Main Authors: Bradley J. Turner, Nicholas J. Parkinson, Kay E. Davies, Kevin Talbot
Format: Article
Language:English
Published: Elsevier 2009-06-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis
Motor neuron
Ribonuclear protein
Spinal muscular atrophy
Survival motor neuron
Superoxide dismutase 1
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109000618

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http://www.sciencedirect.com/science/article/pii/S0969996109000618

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