Neuroprotective Effects of Mitochondria-Targeted Plastoquinone and Thymoquinone in a Rat Model of Brain Ischemia/Reperfusion Injury

Neuroprotective Effects of Mitochondria-Targeted Plastoquinone and Thymoquinone in a Rat Model of Brain Ischemia/Reperfusion Injury

We explored the neuroprotective properties of natural plant-derived antioxidants plastoquinone and thymoquinone (2-demethylplastoquinone derivative) modified to be specifically accumulated in mitochondria. The modification was performed through chemical conjugation of the quinones with penetrating c...

Full description

Bibliographic Details
Main Authors: Denis N. Silachev, Egor Y. Plotnikov, Ljubava D. Zorova, Irina B. Pevzner, Natalia V. Sumbatyan, Galina A. Korshunova, Mikhail V. Gulyaev, Yury A. Pirogov, Vladimir P. Skulachev, Dmitry B. Zorov
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:Molecules
Subjects:
brain ischemia
mitochondria-targeted antioxidants
plastoquinone, thymoquinone
mitochondria
Online Access:http://www.mdpi.com/1420-3049/20/8/14487

Internet

http://www.mdpi.com/1420-3049/20/8/14487

Similar Items