USP37 Promotes Lung Cancer Cell Migration by Stabilizing Snail Protein via Deubiquitination

USP37 Promotes Lung Cancer Cell Migration by Stabilizing Snail Protein via Deubiquitination

Snail is a prominent epithelial–mesenchymal transition (EMT) transcription factor and promotes metastasis. However, Snail protein is unstable and is quickly degraded through ubiquitination-mediated proteasome pathway. Deubiquitinases prevent Snail degradation by regulating the ubiquitination-mediate...

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Bibliographic Details
Main Authors: Jiali Cai, Mengying Li, Xiang Wang, Lei Li, Qi Li, Zhaoyuan Hou, Hao Jia, Shiyuan Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Genetics
Subjects:
deubiquitination
USP37
Snail
cell migration
lung cancer
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.01324/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.01324/full

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