Structural basis of TRPC4 regulation by calmodulin and pharmacological agents

Canonical transient receptor potential channels (TRPC) are involved in receptor-operated and/or store-operated Ca2+ signaling. Inhibition of TRPCs by small molecules was shown to be promising in treating renal diseases. In cells, the channels are regulated by calmodulin (CaM). Molecular details of b...

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Main Authors: Deivanayagabarathy Vinayagam, Dennis Quentin, Jing Yu-Strzelczyk, Oleg Sitsel, Felipe Merino, Markus Stabrin, Oliver Hofnagel, Maolin Yu, Mark W Ledeboer, Georg Nagel, Goran Malojcic, Stefan Raunser
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-11-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/60603