Stitching together multiple data dimensions reveals interacting metabolomic and transcriptomic networks that modulate cell regulation.

Cells employ multiple levels of regulation, including transcriptional and translational regulation, that drive core biological processes and enable cells to respond to genetic and environmental changes. Small-molecule metabolites are one category of critical cellular intermediates that can influence...

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Bibliographic Details
Main Authors: Jun Zhu, Pavel Sova, Qiuwei Xu, Kenneth M Dombek, Ethan Y Xu, Heather Vu, Zhidong Tu, Rachel B Brem, Roger E Bumgarner, Eric E Schadt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC3317911?pdf=render