Genes Bound by ΔFosB in Different Conditions With Recurrent Seizures Regulate Similar Neuronal Functions

Genes Bound by ΔFosB in Different Conditions With Recurrent Seizures Regulate Similar Neuronal Functions

Seizure incidence is increased in Alzheimer’s disease (AD) patients and mouse models, and treatment with the antiseizure drug levetiracetam improves cognition. We reported that one mechanism by which seizures can exert persistent effects on cognition is through accumulation of ΔFosB, a transcription...

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Bibliographic Details
Main Authors: Gabriel S. Stephens, Chia-Hsuan Fu, Corey P. St. Romain, Yi Zheng, Justin J. Botterill, Helen E. Scharfman, Yin Liu, Jeannie Chin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Neuroscience
Subjects:
epilepsy
Alzheimer’s disease
seizure
deltaFosB
epigenetic
pilocarpine
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00472/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.00472/full

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