Molecular mechanisms of HIF-1alpha modulation induced by oxygen tension and BMP2 in glioblastoma derived cells.

Molecular mechanisms of HIF-1alpha modulation induced by oxygen tension and BMP2 in glioblastoma derived cells.

BACKGROUND: Glioblastoma multiforme (GBM) is one of most common and still poorly treated primary brain tumors. In search for new therapeutic approaches, Bone Morphogenetic Proteins (BMPs) induce astroglial commitment in GBM-derived cells in vitro. However, we recently suggested that hypoxia, which i...

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Bibliographic Details
Main Authors: Francesca Pistollato, Elena Rampazzo, Sara Abbadi, Alessandro Della Puppa, Renato Scienza, Domenico D'Avella, Luca Denaro, Geertruy Te Kronnie, David M Panchision, Giuseppe Basso
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2702690?pdf=render

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http://europepmc.org/articles/PMC2702690?pdf=render

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