Next generation sequencing reveals skewing of the T and B cell receptor repertoires in patients with Wiskott Aldrich syndrome

Next generation sequencing reveals skewing of the T and B cell receptor repertoires in patients with Wiskott Aldrich syndrome

The Wiskott Aldrich syndrome (WAS) is due to mutations of the WAS gene encoding for the cytoskeletal WAS protein (WASp), leading to abnormal downstream signaling from the T cell and B cell antigen receptors (TCR, BCR). We hypothesized that the impaired signaling through the TCR and BCR in WAS would...

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Bibliographic Details
Main Authors: Amy E O'Connell, Stefano eVolpi, Kerry eDobbs, Claudia eFiorini, Erdyni eTsitsikov, Helen ede Boer, Isil B Barlan, Jenny M Despotovic, Francisco J Espinosa-Rosales, Celine eHanson, Maria G Kanariou, Roxana eMartinez-Beckerat, Alvaro eMayorga-Sirera, Carmen eMeija-Carvajal, Nesrine eRadwan, Aaron R Weiss, Yu Nee eLee, Sung-Yun ePai, Luigi Daniele Notarangelo
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-07-01
Series:Frontiers in Immunology
Subjects:
Wiskott-Aldrich Syndrome
T lymphocytes
immunodeficiency
next generation sequencing
B lymphocytes
repertoire
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00340/full

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http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00340/full

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