Adenomatous polyposis coli heterozygous knockout mice display hypoactivity and age-dependent working memory deficits

Adenomatous polyposis coli heterozygous knockout mice display hypoactivity and age-dependent working memory deficits

A tumor suppressor gene, Adenomatous polyposis coli (Apc), is expressed in the nervous system from embryonic to adulthood stage, and transmits the Wnt signaling pathway in which schizophrenia susceptibility genes, including T-cell factor 4 (TCF4) and calcineurin (CN), are involved. However, the func...

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Bibliographic Details
Main Authors: Hisatsugu eKoshimizu, Yasuyuki eFukui, Keizo eTakao, Koji eOhira, Koichi eTanda, Kazuo eNakanishi, Keiko eToyama, Masanobu eOshima, Makoto Mark Taketo, Tsuyoshi eMiyakawa
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-12-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
locomotor activity
APC
Behavioral test battery
Hypoactivity
Working memory performance
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2011.00085/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2011.00085/full

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