Shank2 Mutant Mice Display Hyperactivity Insensitive to Methylphenidate and Reduced Flexibility in Social Motivation, but Normal Social Recognition

Shank2 Mutant Mice Display Hyperactivity Insensitive to Methylphenidate and Reduced Flexibility in Social Motivation, but Normal Social Recognition

Mouse models of autism can be used to study evolutionarily conserved mechanisms underlying behavioral abnormalities in social communication and repetitive behaviors. SHANK genes code for synaptic scaffolding proteins at excitatory synapses and mutations in all SHANK genes have been associated with a...

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Bibliographic Details
Main Authors: Elodie Ey, Nicolas Torquet, Fabrice de Chaumont, Julie Lévi-Strauss, Allain-Thibeault Ferhat, Anne-Marie Le Sourd, Tobias M. Boeckers, Thomas Bourgeron
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
mouse models
autism
Shank2
hyperactivity
methylphenidate
social motivation
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00365/full

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https://www.frontiersin.org/article/10.3389/fnmol.2018.00365/full

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