Use of a Hybrid Adeno-Associated Viral Vector Transposon System to Deliver the Insulin Gene to Diabetic NOD Mice

Use of a Hybrid Adeno-Associated Viral Vector Transposon System to Deliver the Insulin Gene to Diabetic NOD Mice

Previously, we used a lentiviral vector to deliver furin-cleavable human insulin (<i>INS-FUR</i>) to the livers in several animal models of diabetes using intervallic infusion in full flow occlusion (FFO), with resultant reversal of diabetes, restoration of glucose tolerance and pancreat...

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Bibliographic Details
Main Authors: Que T. La, Binhai Ren, Grant J. Logan, Sharon C. Cunningham, Neeta Khandekar, Najah T. Nassif, Bronwyn A. O’Brien, Ian E. Alexander, Ann M. Simpson
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cells
Subjects:
diabetes
liver
adeno-associated viral vector
transposon
gene therapy
Online Access:https://www.mdpi.com/2073-4409/9/10/2227

Internet

https://www.mdpi.com/2073-4409/9/10/2227

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