Novel Lipidated Imidazoquinoline TLR7/8 Adjuvants Elicit Influenza-Specific Th1 Immune Responses and Protect Against Heterologous H3N2 Influenza Challenge in Mice

Novel Lipidated Imidazoquinoline TLR7/8 Adjuvants Elicit Influenza-Specific Th1 Immune Responses and Protect Against Heterologous H3N2 Influenza Challenge in Mice

Most licensed seasonal influenza vaccines are non-adjuvanted and rely primarily on vaccine-induced antibody titers for protection. As such, seasonal antigenic drift and suboptimal vaccine strain selection often results in reduced vaccine efficacy. Further, seasonal H3N2 influenza vaccines demonstrat...

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Bibliographic Details
Main Authors: Shannon M. Miller, Van Cybulski, Margaret Whitacre, Laura S. Bess, Mark T. Livesay, Lois Walsh, David Burkhart, Hélène G. Bazin, Jay T. Evans
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
adjuvant
Vaccine
influenza
TLR4 (Toll-like receptor 4)
Influenza challenge model
precision vaccines
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00406/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00406/full

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