Neuroglobin Plays a Protective Role in Arsenite-Induced Cytotoxicity by Inhibition of Cdc42 and Rac1GTPases in Rat Cerebellar Granule Neurons

Neuroglobin Plays a Protective Role in Arsenite-Induced Cytotoxicity by Inhibition of Cdc42 and Rac1GTPases in Rat Cerebellar Granule Neurons

Background and Aims: We have previously shown that neuroglobin (Ngb) expression can be regulated by sodium arsenite (NaAsO2) exposure in rat cerebellar granule neurons (CGNs). However, the precise molecular mechanisms of Ngb action are largely unknown. Ras homolog (Rho) guanosine triphosphatases (Rh...

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Bibliographic Details
Main Authors: Xiaona Liu, Yanhui Gao, Yuan An, Xiaoyan Fu, Yuanyuan Li, Dianjun Sun, Jing Wang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Neuroglobin
Rat Cerebellar Granule Neurons
Cytotoxicity
Rac1 GTPase
Cdc42 GTPase
Sodium Arsenite
Online Access:http://www.karger.com/Article/FullText/430323

Internet

http://www.karger.com/Article/FullText/430323

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