Impact of subinhibitory concentrations of metronidazole on proteome of Clostridioides difficile strains with different levels of susceptibility.

Clostridioides difficile is responsible for various intestinal symptoms from mild diarrhea to severe pseudomembranous colitis and is the primary cause of antibiotic-associated diarrhea in adults. Metronidazole was the first-line treatment for mild to moderate C. difficile infections for 30 years. Ho...

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Bibliographic Details
Main Authors: Tri-Hanh-Dung Doan, Stéphanie Yen-Nicolaÿ, Marie-Françoise Bernet-Camard, Isabelle Martin-Verstraete, Séverine Péchiné
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0241903