Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells

Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells

Cells use multiple feedback controls to regulate metabolism in response to nutrient and signaling inputs. However, feedback creates the potential for unstable network responses. We examined how concentrations of key metabolites and signaling pathways interact to maintain homeostasis in proliferating...

Full description

Bibliographic Details
Main Authors: Yin P Hung, Carolyn Teragawa, Nont Kosaisawe, Taryn E Gillies, Michael Pargett, Marta Minguet, Kevin Distor, Briana L Rocha-Gregg, Jonathan L Coloff, Mark A Keibler, Gregory Stephanopoulos, Gary Yellen, Joan S Brugge, John G Albeck
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-12-01
Series:eLife
Subjects:
homeostasis
single-cell
primary metabolism
glycolysis
Akt
AMPK
Online Access:https://elifesciences.org/articles/27293

Internet

https://elifesciences.org/articles/27293

Similar Items