Identification of metabolic pathways involved in the biotransformation of eslicarbazepine acetate using UPLC-MS/MS, human microsomal enzymes and in silico studies

In the last few decades, metabolite identification and detection have become an integral component of drug discovery process. The detection and depiction of an identified metabolite is significant for the development of safe and effective therapeutic agents as these metabolites may be pharmacologica...

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Bibliographic Details
Main Authors: Asif Husain, Farah Iram, Anees A. Siddiqui, Saeedah Musaed Almutairi, Osama B Mohammed, Shah Alam Khan, Syed Najmul Hejaz Azmi, Nafisur Rahman
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Journal of King Saud University: Science
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1018364720303943