Reducing FLI1 levels in the MRL/lpr lupus mouse model impacts T cell function by modulating glycosphingolipid metabolism.

Reducing FLI1 levels in the MRL/lpr lupus mouse model impacts T cell function by modulating glycosphingolipid metabolism.

Systemic Lupus erythematosus (SLE) is an autoimmune disease caused, in part, by abnormalities in cells of the immune system including B and T cells. Genetically reducing globally the expression of the ETS transcription factor FLI1 by 50% in two lupus mouse models significantly improves disease measu...

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Bibliographic Details
Main Authors: Erin Morris Richard, Thirumagal Thiyagarajan, Marlene A Bunni, Fahmin Basher, Patrick O Roddy, Leah J Siskind, Paul J Nietert, Tamara K Nowling
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3769295?pdf=render

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http://europepmc.org/articles/PMC3769295?pdf=render

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