<i>XPO1</i><sup>E571K</sup> Mutation Modifies Exportin 1 Localisation and Interactome in B-cell Lymphoma

<i>XPO1</i><sup>E571K</sup> Mutation Modifies Exportin 1 Localisation and Interactome in B-cell Lymphoma

The <i>XPO1</i> gene encodes exportin 1 (XPO1) that controls the nuclear export of cargo proteins and RNAs. Almost 25% of primary mediastinal B-cell lymphoma (PMBL) and classical Hodgkin lymphoma (cHL) cases harboured a recurrent <i>XPO1</i> point mutation (NM_003400, chr2:g6...

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Bibliographic Details
Main Authors: Hadjer Miloudi, Élodie Bohers, François Guillonneau, Antoine Taly, Vincent Cabaud Gibouin, Pierre-Julien Viailly, Gaëtan Jego, Luca Grumolato, Fabrice Jardin, Brigitte Sola
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cancers
Subjects:
B-cell lymphoma
XPO1/CRM1
nuclear export
CRISPR–Cas9
proteomics
nuclear import
Online Access:https://www.mdpi.com/2072-6694/12/10/2829

Internet

https://www.mdpi.com/2072-6694/12/10/2829

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