SFPQ and NONO suppress RNA:DNA-hybrid-related telomere instability

SFPQ and NONO suppress RNA:DNA-hybrid-related telomere instability

LncRNA TERRA forms RNA-DNA hybrids at telomere sites leading to telomere instability. Here the authors identify the RNA interacting factors NONO and SFPQ as proteins that interact with TERRA and telomere chromatin and reveal putative roles for these factors in telomere integry maintenance by interfe...

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Bibliographic Details
Main Authors: Eleonora Petti, Valentina Buemi, Antonina Zappone, Odessa Schillaci, Pamela Veneziano Broccia, Roberto Dinami, Silvia Matteoni, Roberta Benetti, Stefan Schoeftner
Format: Article
Language:English
Published: Nature Publishing Group 2019-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08863-1

Internet

https://doi.org/10.1038/s41467-019-08863-1

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