A Novel 3-Phytosterone-9α-Hydroxylase Oxygenation Component and Its Application in Bioconversion of 4-Androstene-3,17-Dione to 9α-Hydroxy-4-Androstene-3,17-Dione Coupling with A NADH Regeneration Formate Dehydrogenase

A Novel 3-Phytosterone-9α-Hydroxylase Oxygenation Component and Its Application in Bioconversion of 4-Androstene-3,17-Dione to 9α-Hydroxy-4-Androstene-3,17-Dione Coupling with A NADH Regeneration Formate Dehydrogenase

9α-Hydroxy-4-androstene-3,17-dione (9-OH-AD) is one of the significant intermediates for the preparation of β-methasone, dexamethasone, and other steroids. In general, the key enzyme that enables the biotransformation of 4-androstene-3,17-dione (AD) to 9-OH-AD is 3-phytosterone-9&a...

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Bibliographic Details
Main Authors: Xian Zhang, Manchi Zhu, Rumeng Han, Youxi Zhao, Kewei Chen, Kai Qian, Minglong Shao, Taowei Yang, Meijuan Xu, Jianzhong Xu, Zhiming Rao
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Molecules
Subjects:
9α-Hydroxy-4-androstene-3,17-dione
3-phytosterone-9α-hydroxylase
hydroxylation
NADH regeneration
Online Access:https://www.mdpi.com/1420-3049/24/14/2534

Internet

https://www.mdpi.com/1420-3049/24/14/2534

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