Functional and Structural Characterization of Nucleic Acid Ligands That Bind to Activated Coagulation Factor XIII

Functional and Structural Characterization of Nucleic Acid Ligands That Bind to Activated Coagulation Factor XIII

Coagulation factor XIII (FXIII) is a protransglutaminase which plays an important role in clot stabilization and composition by cross-linking the α- and γ-chains of fibrin and increasing the resistance of the clot to mechanical and proteolytic challenges. In this study, we selected six DNA aptamers...

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Bibliographic Details
Main Authors: Nasim Shahidi Hamedani, Arijit Biswas, Oliver Rudan, Rosa Tönges, Carlotta Meyring, Fabian Tolle, Günter Mayer, Johannes Oldenburg, Jens Müller, Bernd Pötzsch
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Journal of Clinical Medicine
Subjects:
activated factor XIII
aptamer
SELEX
transglutaminase
aptamer modeling
nucleic acid docking
Online Access:https://www.mdpi.com/2077-0383/10/4/677

Internet

https://www.mdpi.com/2077-0383/10/4/677

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