T cell immunodominance is dictated by the positively selecting self-peptide

Naive T cell precursor frequency determines the magnitude of immunodominance. While a broad T cell repertoire requires diverse positively selecting self-peptides, how a single positively selecting ligand influences naive T cell precursor frequency remains undefined. We generated a transgenic mouse e...

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Bibliographic Details
Main Authors: Wan-Lin Lo, Benjamin D Solomon, David L Donermeyer, Chyi-Song Hsieh, Paul M Allen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-01-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/01457