T cell immunodominance is dictated by the positively selecting self-peptide
Naive T cell precursor frequency determines the magnitude of immunodominance. While a broad T cell repertoire requires diverse positively selecting self-peptides, how a single positively selecting ligand influences naive T cell precursor frequency remains undefined. We generated a transgenic mouse e...
Main Authors: | Wan-Lin Lo, Benjamin D Solomon, David L Donermeyer, Chyi-Song Hsieh, Paul M Allen |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2014-01-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/01457 |
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