Mucosal ribosomal stress-induced PRDM1 promotes chemoresistance via stemness regulation
Kim and Moon find that the transcription factor PRDM1 is induced by ribosomal dysfunction in colorectal cancer (CRC) cells and associated with chemoresistance through a pathway involving IGF signaling. The authors further suggest PRDM1 promotes cancer cell stemness and survival, altogether providing...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-05-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02078-1 |