The Melanocortin MC5R as a New Target for Treatment of High Glucose-Induced Hypertrophy of the Cardiac H9c2 Cells

The Melanocortin MC5R as a New Target for Treatment of High Glucose-Induced Hypertrophy of the Cardiac H9c2 Cells

The study explored the anti-hypertrophic effect of the melanocortin MC5R stimulation in H9c2 cardiac myocytes exposed to high glucose. This has been done by using α-MSH and selective MC5R agonists and assessing the expression of GLUT4 and GLUT1 transporters, miR-133 and urotensin receptor levels as...

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Bibliographic Details
Main Authors: Maria Consiglia Trotta, Rosa Maisto, Nicola Alessio, Anca Hermenean, Michele D’Amico, Clara Di Filippo
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Physiology
Subjects:
cardiac hypertrophy
melanocortin 5 receptor agonism
glucose content
PI3K
GLUT1
GLUT4
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01475/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.01475/full

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