DNA G-Quadruplexes Contribute to CTCF Recruitment

DNA G-Quadruplexes Contribute to CTCF Recruitment

G-quadruplex (G4) sites in the human genome frequently colocalize with CCCTC-binding factor (CTCF)-bound sites in CpG islands (CGIs). We aimed to clarify the role of G4s in CTCF positioning. Molecular modeling data suggested direct interactions, so we performed in vitro binding assays with quadruple...

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Bibliographic Details
Main Authors: Polina Tikhonova, Iulia Pavlova, Ekaterina Isaakova, Vladimir Tsvetkov, Alexandra Bogomazova, Tatjana Vedekhina, Artem V. Luzhin, Rinat Sultanov, Vjacheslav Severov, Ksenia Klimina, Omar L. Kantidze, Galina Pozmogova, Maria Lagarkova, Anna Varizhuk
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
G-quadruplex
chromatin remodeling
CpG methylation
CTCF
HMG proteins
Online Access:https://www.mdpi.com/1422-0067/22/13/7090

Internet

https://www.mdpi.com/1422-0067/22/13/7090

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