HDAC6: A Novel Histone Deacetylase Implicated in Pulmonary Arterial Hypertension

HDAC6: A Novel Histone Deacetylase Implicated in Pulmonary Arterial Hypertension

Abstract Pulmonary arterial hypertension (PAH) is a vascular remodeling disease with limited therapeutic options. Although exposed to stressful conditions, pulmonary artery (PA) smooth muscle cells (PASMCs) exhibit a “cancer-like” pro-proliferative and anti-apoptotic phenotype. HDAC6 is a cytoplasmi...

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Bibliographic Details
Main Authors: Olivier Boucherat, Sophie Chabot, Roxane Paulin, Isabelle Trinh, Alice Bourgeois, François Potus, Marie-Claude Lampron, Caroline Lambert, Sandra Breuils-Bonnet, Valérie Nadeau, Renée Paradis, Elena A. Goncharova, Steeve Provencher, Sébastien Bonnet
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-04874-4

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https://doi.org/10.1038/s41598-017-04874-4

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