Perturbation of Thymocyte Development Underlies the PRRS Pandemic: A Testable Hypothesis

Perturbation of Thymocyte Development Underlies the PRRS Pandemic: A Testable Hypothesis

Porcine reproductive and respiratory syndrome virus (PRRSV) causes immune dysregulation during the Critical Window of Immunological Development. We hypothesize that thymocyte development is altered by infected thymic antigen presenting cells (TAPCs) in the fetal/neonatal thymus that interact with do...

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Bibliographic Details
Main Authors: John E. Butler, Marek Sinkora, Gang Wang, Katerina Stepanova, Yuming Li, Xuehui Cai
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
hypergammaglobulinemia
PRRS virus
T cell repertoire
thymic atrophy
hypothesis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01077/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01077/full

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