Heme Drives Oxidative Stress-Associated Cell Death in Human Neutrophils Infected with Leishmania infantum

Heme Drives Oxidative Stress-Associated Cell Death in Human Neutrophils Infected with Leishmania infantum

Free heme is an inflammatory molecule capable of inducing migration and activation of neutrophils. Here, we examine the heme-driven oxidative stress-associated cell death mechanisms in human neutrophils infected with Leishmania infantum, an etiologic agent of visceral leishmaniasis (VL). We first pe...

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Bibliographic Details
Main Authors: Graziele Quintela-Carvalho, Nívea F. Luz, Fabiana S. Celes, Dalila L. Zanette, Daniela Andrade, Diego Menezes, Natália M. Tavares, Claudia I. Brodskyn, Deboraci B. Prates, Marilda S. Gonçalves, Camila I. de Oliveira, Roque P. Almeida, Marcelo T. Bozza, Bruno B. Andrade, Valeria M. Borges
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
Leishmania infantum
heme
iron
neutrophils
cell death
heme oxygenase 1
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01620/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01620/full

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