Interrogating the Essential Bacterial Cell Division Protein FtsQ with Fragments Using Target Immobilized NMR Screening (TINS)

Interrogating the Essential Bacterial Cell Division Protein FtsQ with Fragments Using Target Immobilized NMR Screening (TINS)

The divisome is a large protein complex that regulates bacterial cell division and therefore represents an attractive target for novel antibacterial drugs. In this study, we report on the ligandability of FtsQ, which is considered a key component of the divisome. For this, the soluble periplasmic do...

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Bibliographic Details
Main Authors: Marjolein Glas, Eiso AB, Johan Hollander, Gregg Siegal, Joen Luirink, Iwan de Esch
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:International Journal of Molecular Sciences
Subjects:
bacterial cell division
antibacterials
<i>Escherichia coli</i>
fragment screening
divisome
FtsQ
NMR
TINS
Online Access:https://www.mdpi.com/1422-0067/20/15/3684

Internet

https://www.mdpi.com/1422-0067/20/15/3684

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