Ivabradine-Stimulated Microvesicle Release Induces Cardiac Protection against Acute Myocardial Infarction

Ivabradine-Stimulated Microvesicle Release Induces Cardiac Protection against Acute Myocardial Infarction

Ivabradine can reduce heart rate through inhibition of the current I(<i>f</i>) by still unexplored mechanisms. In a porcine model of ischemia reperfusion (IR), we found that treatment with 0.3 mg/kg Ivabradine increased plasma release of microvesicles (MVs) over Placebo, as detected by f...

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Bibliographic Details
Main Authors: Rafael Ramirez-Carracedo, Laura Tesoro, Ignacio Hernandez, Javier Diez-Mata, Laura Botana, Marta Saura, Marcelo Sanmartin, Jose Luis Zamorano, Carlos Zaragoza
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
acute myocardial infarction
ischemia/reperfusion
microvesicles
ivabradine
EMMPRIN
Online Access:https://www.mdpi.com/1422-0067/21/18/6566

Internet

https://www.mdpi.com/1422-0067/21/18/6566

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