Chondrocytes Derived From Mesenchymal Stromal Cells and Induced Pluripotent Cells of Patients With Familial Osteochondritis Dissecans Exhibit an Endoplasmic Reticulum Stress Response and Defective Matrix Assembly

Chondrocytes Derived From Mesenchymal Stromal Cells and Induced Pluripotent Cells of Patients With Familial Osteochondritis Dissecans Exhibit an Endoplasmic Reticulum Stress Response and Defective Matrix Assembly

Familial osteochondritis dissecans (FOCD) is an inherited skeletal defect characterized by the development of large cartilage lesions in multiple joints, short stature, and early onset of severe osteoarthritis. It is associated with a heterozygous mutation in the ACAN gene, resulting in a Val‐Met re...

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Bibliographic Details
Main Authors: Maojia Xu, Eva-Lena Stattin, Georgina Shaw, Dick Heinegård, Gareth Sullivan, Ian Wilmut, Alan Colman, Patrik Önnerfjord, Areej Khabut, Anders Aspberg, Peter Dockery, Timothy Hardingham, Mary Murphy, Frank Barry
Format: Article
Language:English
Published: Wiley 2016-09-01
Series:Stem Cells Translational Medicine
Subjects:
Osteoarthritis
Familial osteochondritis dissecans
Mesenchymal stromal cells
Induced pluripotent stem cells
Stem cell disease models
Cellular pathology
Online Access:https://doi.org/10.5966/sctm.2015-0384

Internet

https://doi.org/10.5966/sctm.2015-0384

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