Vitamin E treatment in NAFLD patients demonstrates that oxidative stress drives steatosis through upregulation of de-novo lipogenesis

Vitamin E treatment in NAFLD patients demonstrates that oxidative stress drives steatosis through upregulation of de-novo lipogenesis

Oxidative stress (OS) in non-alcoholic fatty liver disease (NAFLD) promotes liver injury and inflammation. Treatment with vitamin E (α-tocopherol, αT), a lipid-soluble antioxidant, improves liver injury but also decreases steatosis, thought to be upstream of OS, through an unknown mechanism. To eluc...

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Bibliographic Details
Main Authors: Maren C. Podszun, Ahmad S. Alawad, Shilpa Lingala, Nevitt Morris, Wen-Chun A. Huang, Shanna Yang, Megan Schoenfeld, Adam Rolt, Ronald Ouwerkerk, Kristin Valdez, Regina Umarova, Yanling Ma, Syeda Zaheen Fatima, Dennis D. Lin, Lakshmi S. Mahajan, Niharika Samala, Pierre-Christian Violet, Mark Levine, Robert Shamburek, Ahmed M. Gharib, David E. Kleiner, H. Martin Garraffo, Hongyi Cai, Peter J. Walter, Yaron Rotman
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Redox Biology
Subjects:
Non-alcoholic fatty liver disease
NAFLD
Vitamin E
Oxidative stress
de novo lipogenesis
S1P
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720309150

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http://www.sciencedirect.com/science/article/pii/S2213231720309150

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