The expression of miRNAs is associated with tumour genome instability and predicts the outcome of ovarian cancer patients treated with platinum agents

Abstract miRNAs, a class of short but stable noncoding RNA molecules, have been revealed to play important roles in the DNA damage response (DDR). However, their functions in cancer genome instability and the consequent clinical effect as the response to chemotherapy have not been fully elucidated....

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Bibliographic Details
Main Authors: Tianzhen Wang, Guangyu Wang, Xiaoxiao Zhang, Di Wu, Lei Yang, Guangyou Wang, Dapeng Hao
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-12259-w