Optimized blanching reduces the host cell protein content and substantially enhances the recovery and stability of two plant derived malaria vaccine candidates

Optimized blanching reduces the host cell protein content and substantially enhances the recovery and stability of two plant derived malaria vaccine candidates

Plants provide an advantageous expression platform for biopharmaceutical proteins because of their low pathogen burden and potential for inexpensive, large-scale production. However, the purification of target proteins can be challenging due to issues with extraction, the removal of host cell protei...

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Bibliographic Details
Main Authors: Stephan eMenzel, Tanja eHolland, Alexander eBoes, Holger eSpiegel, Johanna eBolzenius, Rainer eFischer, Johannes Felix Buyel
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Plant Science
Subjects:
downstream processing
Design of Experiments
vaccine development
blanching
Heat precipitation
Plant-derived biopharmaceuticals
Online Access:http://journal.frontiersin.org/Journal/10.3389/fpls.2016.00159/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fpls.2016.00159/full

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