Human CD8+ T Cells Release Extracellular Traps Co-Localized With Cytotoxic Vesicles That Are Associated With Lesion Progression and Severity in Human Leishmaniasis

Human CD8+ T Cells Release Extracellular Traps Co-Localized With Cytotoxic Vesicles That Are Associated With Lesion Progression and Severity in Human Leishmaniasis

Cell death plays a fundamental role in mounting protective and pathogenic immunity. Etosis is a cell death mechanism defined by the release of extracellular traps (ETs), which can foster inflammation and exert microbicidal activity. While etosis is often associated with innate cells, recent studies...

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Bibliographic Details
Main Authors: Carolina Cattoni Koh, Amanda B. Wardini, Millene Vieira, Livia S. A. Passos, Patrícia Massara Martinelli, Eula Graciele A. Neves, Lis Riberido do Vale Antonelli, Daniela Faria Barbosa, Teresiama Velikkakam, Eduardo Gutseit, Gustavo B. Menezes, Rodolfo Cordeiro Giunchetti, Paulo Roberto Lima Machado, Edgar M. Carvalho, Kenneth J. Gollob, Walderez Ornelas Dutra
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
extracellular traps
CD8+ T cells
etosis
cytotoxicity
pathology
leishmaniasis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.594581/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.594581/full

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