Increased Efficacy of Histone Methyltransferase G9a Inhibitors Against MYCN-Amplified Neuroblastoma

Increased Efficacy of Histone Methyltransferase G9a Inhibitors Against MYCN-Amplified Neuroblastoma

Targeted inhibition of proteins modulating epigenetic changes is an increasingly important priority in cancer therapeutics, and many small molecule inhibitors are currently being developed. In the case of neuroblastoma (NB), a pediatric solid tumor with a paucity of intragenic mutations, epigenetic...

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Bibliographic Details
Main Authors: Jacob Bellamy, Marianna Szemes, Zsombor Melegh, Anthony Dallosso, Madhu Kollareddy, Daniel Catchpoole, Karim Malik
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Oncology
Subjects:
G9a inhibitors
neuroblastoma
MYCN
apoptosis
epigenetic therapy
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00818/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00818/full

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