NF-κB in T-cell Acute Lymphoblastic Leukemia: Oncogenic Functions in Leukemic and in Microenvironmental Cells

NF-κB in T-cell Acute Lymphoblastic Leukemia: Oncogenic Functions in Leukemic and in Microenvironmental Cells

Two main NF-κB signaling pathways, canonical and noncanonical, performing distinct functions in organisms have been characterized. Identification of mutations in genes encoding components of these NF-κB signaling pathways in lymphoid malignancies confirmed their key role in leukemogenesis. T-cell ac...

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Bibliographic Details
Main Authors: Mónica T. Fernandes, Nuno R. dos Santos, Ricardo C. da Silva, Marinella N. Ghezzo
Format: Article
Language:English
Published: MDPI AG 2010-11-01
Series:Cancers
Subjects:
NF-κB
signaling
T cell
leukemia
lymphoma
NOTCH1
microenvironment
Online Access:http://www.mdpi.com/2072-6694/2/4/1838/

Internet

http://www.mdpi.com/2072-6694/2/4/1838/

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