Effects of Lissoclibadins and Lissoclinotoxins, Isolated from a Tropical Ascidian Lissoclinum cf. badium, on IL-8 production in a PMA-stimulated Promyelocytic Leukemia Cell Line

Effects of Lissoclibadins and Lissoclinotoxins, Isolated from a Tropical Ascidian Lissoclinum cf. badium, on IL-8 production in a PMA-stimulated Promyelocytic Leukemia Cell Line

The effects of seven compounds 1-7, isolated from a tropical ascidian Lissoclinum cf. badium, on IL-8 production in PMA-stimulated HL-60 cells were examined. Lissoclibadins 2 (2) and 3 (3) and lissoclinotoxin F (5) increased the IL-8 production in a dose-dependent manner. Compounds 2 and 5 are struc...

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Bibliographic Details
Main Authors: Takeshi Fujiwara, Hongwei Liu, Kazuyo Ukai, Remy E. P. Mangindaan, Masataka Mochizuki, Michio Namikoshi, Taiko Oda
Format: Article
Language:English
Published: MDPI AG 2006-02-01
Series:Marine Drugs
Subjects:
Tropical ascidian
Lissoclinum cf. badium
Lissoclibadins
Lissoclinotoxins
IL- 8
HL-60 cells
Online Access:http://www.mdpi.com/1660-3397/4/1/15/

Internet

http://www.mdpi.com/1660-3397/4/1/15/

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